Results and Impact – PEPFAR

The United States President’s Emergency Plan for AIDS Relief

Over the past 21 years, PEPFAR has had remarkable lifesaving results. As of September 30, 2023, the U.S. President Emergency Plan for AIDS Relief (PEPFAR) supported antiretroviral treatment for nearly 20.5 million people.

Image with 10 horizontal ribbon in different colors each with a related symbol to the context reading: PEPFAR’s Latest Global Results & Projections Over the past 20 years, PEPFAR has had remarkable lifesaving results around the world – saving more than 25 million lives and enabling more than 5.5 million babies to be born HIV-free. As of Sept. 30, 2023, PEPFAR supported life-saving antiretroviral treatment for 20.47 million men, women, and children. PEPFAR supported 1.95 million people to newly enroll for antiretroviral pre-exposure prophylaxis (PrEP) to prevent HIV infection in FY 2023—up from 1.5 million new PrEP enrollments in FY 2022. PEPFAR has directly supported more than 327,000 health workers to deliver quality HIV-related prevention, treatment and supportive services in clinics and communities in FY 2023. PEPFAR has provided 32.5 million voluntary medical male circumcisions in East and Southern Africa to help prevent new HIV infections since 2007. Uptake for the procedure rebounded in the past year after a decline since onset of the COVID-19 pandemic. In FY 2023, 2.5 million adolescent girls and young women were reached through DREAMS HIV prevention services. In FY 2023, PEPFAR supported 71.1 million people to receive HIV testing services. In FY 2023, PEPFAR supported 7 million orphans, vulnerable children, and their caregivers with critical care and support. PEPFAR has supported 13.4 million people on antiretroviral therapy for HIV to be initiated on tuberculosis preventive therapy since 2017. Using FY 2023 results in 12 high-disease burden countries, PEPFAR projects a striking impact from 2024-2030 to prevent at least 5.2 million AIDS-related deaths and 6.4 million new HIV infections (including 1 million new infections among children), as well as prevent more than 4 million children from being orphaned due to AIDS. If the program was halted, AIDS-related deaths in these countries are projected to increase rapidly by more than 400% by 2030 and the number of children orphaned due to AIDS could double.

PEPFAR has enabled 5.5 million babies to be born HIV-free to mothers living with HIV. The program has provided critical care and support for 7 million orphans, vulnerable children, and their caregivers so they can survive and thrive.

PEPFAR has helped prevent HIV infection in men and boys, including by supporting 32.5 million voluntary medical male circumcisions in east and Southern Africa. Since 2015, new HIV diagnoses among adolescent girls and young women have declined in all geographic areas implementing the PEPFAR-led DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe) public-private partnership.

PEPFAR’s investments also strengthen the systems that drive effective, efficient, and sustainable health care. PEPFAR is directly supporting 327,000 health workers to deliver and improve HIV care and other health services, creating a lasting health system for partner countries to confront other current and future health challenges.

U.S. Department of State

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